PimCell™

PimCell^® Silicone Devices is a family of easy-to-use microfluidic inserts specifically developed to handle the requirements of larger tissues in experiments and assays with up to 24 wells with single well diameter 15,5 mm or more. The PimCell^® inserts are compatible with a wide range of laboratory automation / robotic fluid handling and imaging modalities. Each insert supports an open top cell culture chamber connected to at least one enclosed microfluidic channel without any physical barrier between. A partial wall from the top surface of the device chamber is used as a capillary pressure barrier (CPB) to separate the chamber and the side channel(s) allowing an uninterrupted interface. Each chamber has an additional free space above allowing unobstructed view and apical access to the culture. A single insert can be connected to adaptors which serve as medium reservoirs for a gravity driven perfusion supporting in vitro reconstruction of 3D tissue microenvironment. The PimCell^® inserts are produced in cleanroom facilities and clean areas to prevent physical impurities but not sterilized and need end user sterilization and assembly depending on your needs. The PimCell^® family is designed as an alternative to existing microfluidic devices which have relative large space without sufficient perfusion inside hydrogel-filled microfluidic channels. The open top cell culture chamber eliminates the need of a hydrogel introduction channel with its dead volume. Any desired 3D cell culture support can be placed directly near the microfluidic channel. The direct advantage is an opportunity to create a novel or to upgrade existing in vitro models for producing more valuable and reliable data. In order to reduce waste and protect the environment all PimCell^® inserts are packaged in biodegradable PLA containers and bags when delivered.