Why Glass Bottom Dishes Trump Glass Bottom Plates in Microscopy

Published on 19 October 2023 at 16:23

Microscopy is an invaluable tool in the world of science, allowing us to peer into the hidden realms of the microscopic world. When it comes to microscopy, the choice of equipment can greatly impact the quality of your research. One critical decision is whether to use glass bottom dishes or glass bottom plates. In this blog, we'll explore why glass bottom dishes are often considered the superior choice for microscopy applications.


Stability and Handling

Glass bottom dishes offer researchers a robust and stable platform to work with. The dish format provides an ergonomic grip, making them easier to handle during sample preparation, imaging, and washing. This stability ensures that your samples remain undisturbed during the crucial stages of microscopy.


Sample Containment

Keeping your samples intact and in their natural state is essential, especially for live cell imaging. Glass bottom dishes excel in this area, as they can hold a larger volume of liquid while minimizing the risk of leakage or evaporation. This advantage is particularly valuable for experiments that require precise control over the sample environment.



Research often involves a variety of microscopy techniques, such as brightfield, phase contrast, differential interference contrast (DIC), and fluorescence microscopy. Glass bottom dishes can accommodate all these methods, making them versatile and suitable for a wide range of applications. This adaptability means you can use them for multiple experiments without the need for different equipment.


Compatibility with Coverslips

Coverslips play a vital role in protecting samples, maintaining a controlled environment, and reducing contamination. Glass bottom dishes readily accommodate coverslips, providing an additional layer of protection and optical clarity. This feature is particularly crucial for long-term time-lapse experiments and live cell imaging.


Sample Observation

When it comes to obtaining clear, high-resolution images, the flat and optically clear surface of glass bottom dishes is a significant advantage. These dishes minimize optical aberrations and distortions, ensuring that the quality of your microscopy results remains top-notch.


Microscope Stage Compatibility

Most microscopes are designed to work seamlessly with standard glass bottom dishes. This compatibility simplifies the process of positioning and focusing on the sample. Researchers can save time and effort, focusing on the science rather than equipment adjustments.



Last but not least, glass bottom dishes are widely available in various sizes, formats, and materials. This availability ensures that you can find a suitable dish for your specific experiment, regardless of its scale or requirements. 



In the world of microscopy, the choice between glass bottom dishes and glass bottom plates can significantly impact the quality and success of your experiments. While glass bottom plates have their place, glass bottom dishes stand out for their stability, sample containment, versatility, compatibility with coverslips, and optimal sample observation.

Ultimately, the choice between the two will depend on your specific microscopy needs. However, glass bottom dishes are often favored for their user-friendly design and adaptability across various microscopy techniques, making them a top choice for many researchers.

Innovative cell culture devices represent groundbreaking instruments for researchers and scientists across diverse domains, including biology, biotechnology, and pharmaceuticals. These devices often introduce novel features or capabilities that set them apart from conventional cell culture techniques. An exemplary illustration of this innovation is the microfluidic PimCell® Dish, which combines organ-on-a-chip technology with a glass-bottom dish.


When unique cell culture devices like the PimCell® Dishes debut in the commercial market, they usher in fresh opportunities for researchers and have the potential to expedite progress within their respective fields.


Are you contemplating the integration of the PimCell® Dish for your research requirements?


Please have a look at our microfluidic PimCell® Tube and PimCell® Voice Dishes.